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Our flu uncoating paper is published online in Nature Microbiology!!!

Influenza A virus is a pathogen of great medical impact. To develop novel antiviral strategies, it is essential to understand the molecular aspects of virus–host cell interactions in detail. During entry, the viral ribonucleoproteins (vRNPs) that carry the RNA genome must be released from the incoming particle before they can enter the nucleus for replication. The uncoating process is facilitated by histone deacetylase 6 (ref.1 ). However, the precise mechanism of shell opening and vRNP debundling is unknown. Here, we show that transportin 1, a member of the importin-β family proteins, binds to a PY-NLS2 sequence motif close to the amino terminus of matrix protein (M1) exposed during acid pr

Yasu wins Best Poster Prize at CMM Awayday

The annual new year's CMM Awayday was held at the Conference Centre in Wills Hall, University of Bristol. Yasu made a fantastic start to 2019 by winning the First Prize in the poster session (out of 40+ posters) for presenting our publication "Influenza virus uses transportin 1 for vRNP debundling during cell entry" (Miyake et al., Nature Microbiology, in press). Congratulations Yasu!!

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